Fig. 1

Angiogenesis is targetable in CD8-positive immunomodulatory TNBC patients. A Conceptual basis of the study to optimize inclusion criteria and find co-target pathways for effective TNBC immunotherapy. B Differences in stromal and intratumoral TILs between the CD8⁺ cells < 10% and CD8⁺ cells ≥ 10% subgroups. C-D Differences in immunostimulatory and immune checkpoint molecules between the CD8⁺ cells < 10% and CD8⁺ cells ≥ 10% subgroups. E Association of the indicated pathways with CD8⁺ cell infiltration in TNBC patients. Fifty gene sets from the MSigDB hallmark gene sets (v7.4) were included, and symbols with FDR < 0.005 are presented in colors in the plot. F Clinical characteristics associated with the angiogenesis enrichment score. G Association of representative molecules in different immune-related categories with the angiogenesis enrichment score. TNBC, triple-negative breast cancer; TILs, tumor-infiltrating lymphocytes; BLIS, basal-like immune-suppressed; LAR, luminal androgen receptor; IM, immunomodulatory; MES, mesenchymal-like