Fig. 6

CircMAP3K4-455aa promotes HCC growth in vivo. A-C Huh7 xenograft growth (A), tumor weights (B), and photographs (C) of the circMAP3K4 (n = 7), circMAP3K4-mut (n = 6), and control groups (n = 6). D-F Huh7 xenograft growth (D), tumor weights (E), and photographs (F) of the circMAP3K4-455aa (n = 6) and vector groups (n = 6). G. Representative images of HCC tissue stained with HE, Ki67, and TUNEL under the indicated conditions. cMAP3K4 or cMAP, circMAP3K4; HE, Hematoxylin–Eosin staining; TUNEL, TdT-mediated dUTP nick end labeling. * p < 0.05, ** p < 0.01, and *** p < 0.001 in t-test (B, E) or two-way ANOVA (A, D)