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Fig. 1 | Molecular Cancer

Fig. 1

From: Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

Fig. 1

UbcH5c (also named UBE2D3) is overexpressed in pancreatic cancer and correlated with the poor prognosis of patients with this disease. a Heatmap showing mRNA expression level correlation of E2s with IAP family members, including cIAP1/BIRC2, cIAP2/BIRC3, and XIAP. b Kaplan–Meier survival analysis for the association of UbcH5c expression with overall survival of patients in the TCGA pancreatic cancer dataset. c UbcH5c mRNA expression is upregulated in the pancreatic tumor tissues compared with it in the normal tissues group from TCGA TARGET GTEx dataset. d UbcH5c mRNA expression is upregulated in the pancreatic tumor samples compared with paired adjacent nontumorous samples from TCGA dataset. e Representative IHC images on tissue microarray probed with the anti-UbcH5c antibody in Human Protein Atlas. f Correlation analysis of UbcH5c and indicated genes mRNA expression levels in the TCGA pancreatic cancer dataset. Correlation coefficient r and P values are shown on the graphs. * P < 0.05, ** P < 0.01, *** P < 0.001

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Molecular Cancer

ISSN: 1476-4598