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Fig. 2 | Molecular Cancer

Fig. 2

From: Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

Fig. 2

DHPO directly targets UbcH5c. a, b and c The predicted binding mode of DHPO to UbcH5c by docking analysis. d Chemical structure of DHPO. e and f The binding affinity of DHPO to UbcH5c was evaluated by surface plasmon resonance analysis. g The DHPO-UbcH5c binding was examined in Panc1 and SW1990 cells using cellular thermal shift assays and western blot

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Molecular Cancer

ISSN: 1476-4598