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Fig. 3 | Molecular Cancer

Fig. 3

From: Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

Fig. 3

DHPO inhibits cell proliferation, triggers apoptosis, and prevents migration and invasion in pancreatic cancer cells in vitro. a Effects of DHPO on the viability of human pancreatic cancer cell lines versus normal pancreatic cells were evaluated by 72-h CCK8 assays. b and c The colony-formation assays were performed and colony numbers were counted. d and e Representative results of Annexin V-FITC/PI staining and quantitative analysis after the DHPO treatment for 48 h. f and h Wound healing assays after DHPO treatment for 24 h. g and i Transwell invasion assay was performed by the 24-transwell system, followed by quantitative analysis. * P < 0.05, ** P < 0.01, *** P < 0.001

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