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Fig. 4 | Molecular Cancer

Fig. 4

From: Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

Fig. 4

Transcriptome in Panc1 cells identifies downregulated pathways. a PCA of transcriptomes with or without DHPO treatment represented in a two-dimensional space. b Volcano plot showed the differentially expressed genes between DHPO-treated and untreated Panc1 cells. c and d GO analysis and KEGG analysis for the significantly downregulated genes by DHPO compared to control in Panc1 cells. The top 10 downregulated pathways were listed. e GSEA results demonstrating a strong association with TNFα signaling via NF-κB (from hallmark MSigDB signatures), following DHPO treatment in Panc1 cells. f Heatmap shows expression levels of TNFα signaling via NF-κB genes in Panc1 cells with or without DHPO treatment

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