Fig. 1

A large number of lncRNAs are dysregulated in ESCC. a Ten pairs of ESCC tumor tissues (T) and matched adjacent normal tissues (N) were collected and subjected to RNA-seq analysis followed by hierarchical cluster analysis. b Volcano plot shows the fold change against the q value for genes as described in (a). Blue and red dots represent genes with significant change (q < 0.05, FC > 1.5). c-d Pie chart shows the differentially expressed mRNAs (c) and lncRNAs (d) in ESCC tumor samples according to RNA-seq. e–f Heat map displays the expression of the differentially expressed mRNAs (e) and lncRNAs (f) as shown in (c) and (d), respectively. g Flowchart to search for clinical-relevant lncRNAs in ESCC. h–k The relative expression of LINC00680 (h), AC092910.3 (i), MIR4435-2HG (j), and GSEC (k) in ESCC tumor and normal tissues from lnCAR database. l-o The correlation between prognosis and the expression of LINC00680 (l), AC092910.3 (m), MIR4435-2HG (n), and GSEC (o) in ESCC patients from lnCAR database