Clinical significance of FBXW7 loss of function in human cancers

Fan, Jingyi; Bellon, Marcia; Ju, Mingyi; Zhao, Lin; Wei, Minjie; Fu, Liwu; Nicot, Christophe

doi:10.1186/s12943-022-01548-2

Molecular Cancer

Table 1 Non-coding RNA regulation of FBXW7

From: Clinical significance of FBXW7 loss of function in human cancers

RNA type	ncRNA	Research subject	FBXW7 expression	Results or effects of the research	References
miRNAs	miR-18b-3p	Hepatic fibrosis	down-regulated	Promote liver fibrosis, promote tumor proliferation, and promote inflammation	[41]
	miR-23a	Colorectal cancer	down-regulated	Promote malignant transformation of colorectal cancer	[42]
	miR-25	Hepatocellular Carcinoma	down-regulated	Invasion and migration	[43]
	miR-25	Prostatic Small Cell Neuroendocrine Carcinoma	down-regulated	Upregulate AURKA, promote tumor proliferation	[44]
	miR-27a	Bronchial epithelial cell carcinoma	down-regulated	Malignant transformation induced by the viral oncoprotein ST	[45]
	miR-27b-3p	Multiple myeloma	down-regulated	Mcl-1 is upregulated and produces apoptosis resistance	[46]
	miR-32	Breast cancer	down-regulated	Inhibits apoptosis and promotes proliferation and migration of breast cancer cells.	[47]
	miR-92a	Cervical Cancer	down-regulated	Promote proliferation of cervical cancer cells	[48]
	miR-92a-3p	Colorectal cancer	down-regulated	Activation of Wnt/β-catenin pathway promotes cell stemness, EMT, metastasis and 5-FU/L-OHP resistance in CRC	[39]
	miR-92a-3p	Gastric cancer	down-regulated	Promote invasive migration of gastric cancer	[49]
	miR-92a-3p	Hepatocellular carcinoma	down-regulated	Promotes proliferation and cell cycle transition from G1 to S phase, and inhibits apoptosis in HCC cells	[40]
	miR-101	Bone marrow mesenchymal stem cell	down-regulated	Upregulate HIF1α	[50]
	miR-144	Nasopharyngeal carcinoma	down-regulated	Upregulate HIF1α	[51]
	miR-155	Glioma	down-regulated	Enhance the tumor cell viability	[52]
	miR-155-3p	Hepatocellular carcinoma	down-regulated	Promote HCC cell proliferation	[53]
	miR-182	Breast cancer	down-regulated	Upregulate the HIF-1α-VEGF-A axis and promotes tumor invasion and migration	[54]
	miR-182	Colon adenoma	down-regulated	Induced transformation of adenoma to adenocarcinoma	[55]
	miR-197-3p	Gastric cancer	down-regulated	Up-regulate cyclinD1, EMT, YAP1, down-regulate CCDC6	[56]
	miR-223	Gastric cancer	down-regulated	Promote the cisplatin resistance; reduces trastuzumab sensitivity	[36, 57]
	miR-223	Oesophageal squamous cell carcinoma	down-regulated	Intervention of poor patient prognosis	[37]
	miR-223	Colorectal cancer	down-regulated	Increases endogenous cell cycle protein E protein and activity	[58]
	miR-367	Lung cancer	down-regulated	Promotes tumor cell invasion and migration and is associated with poor prognosis	[59]
	miR-367	Hepatocellular carcinoma	down-regulated	Promote EMT	[60]
	miR-500a-3p	Gastric cancer	down-regulated	Increase cisplatin resistance	[61]
	miR-503	Colon adenoma	down-regulated	Induced transformation of adenoma to adenocarcinoma	[55]
	miR-586	Lung cancer	down-regulated	Promote tumorigenesis	[62]
	miR-5000-3p	Laryngocarcinoma	down-regulated	Promote the invasion and migration of laryngeal cancer cells	[63]
lncRNAs	lncRNA-CASC2	Hepatocellular carcinoma	up-regulated	Inhibit EMT	[60]
	lncRNA-MALAT1	Glioma	up-regulated	Suppresse tumor cell viability	[52]
	lncRNA-MIF	Lung cancer	up-regulated	Inhibit cMyc, inhibits aerobic glycolysis and tumorigenesis	[62]
	lncRNA-MIR22HG	Laryngocarcinoma	up-regulated	Inhibit the invasion and migration of laryngeal cancer cells	[63]
	lncRNA-MT1JP	Gastric cancer	up-regulated	Inhibit invasive migration of gastric cancer	[49]
	lncRNA-FRE1L4	Gastric cancer	up-regulated	Inhibit prostate cancer progression	[49]
	lncRNA-TTN-AS1	Esophageal Squamous Cell Carcinoma	up-regulated	Competitive binding of miR-133b promotes the expression of transcription factor Snail1, leading to an EMT cascade response	[64]
circRNAs	hsa_circ_001988^a	Gastric cancer	up-regulated	Up-regulate cyclinD1, EMT, YAP1, down-regulate CCDC6	[56]
	circFBXW4	Hepatic fibrosis	up-regulated	Inhibit liver fibrosis, inhibit tumor proliferation, anti-inflammatory	[41]
	FBXW7-185aa	Glioma	-	Reduce the expression of c-Myc expression, associated with good patient survival	[65]
	circ-FBXW7^a	Colon adenoma	-	Decrease the expression of NEK2, mTOR and PTEN to induce tumor suppression	[66]

The table describes all currently known regulatory roles of non-coding RNA (ncRNA), including miRNAs, lnc-RNAs and circ-RNAs, affecting FBXW7 expression which can be up-regulated or down-regulated. The cancer type and published biological consequences of FBXW7 alterations is indicated in the second and fourth columns. References for which the ncRNA was described is listed on the right end-side of the table. ^aFor cirRNAs, circ-FBXW7 goes by several names, including has_circ_001988 and circ_022705

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ISSN: 1476-4598

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