Fig. 1
From: LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer
LSD1 KO can inhibit tumor growth by promoting T-cell response in GC. a Relationship between LSD1 and CD8 + T-cell infiltration level in GC analyzed by TIMER2.0. b Relationship between LSD1 and CD8 mRNA in GC using data from TCGA database (n = 407). c and d Images of tumors, tumor weight, and tumor volume curves of 615 mice (c) and BALB/c nude mice (d) bearing 2.5 × 105 MFC cells whether LSD1 was abrogated or not (The data are presented as the mean ± SD, n = 6). e Growth curves of BGC-823 and MGC-803 cells in the presence or absence of LSD1. f Cell survival of BGC-823 and MGC-803 cells in the presence or absence of LSD1, treated with anti-CD3/CD28-activated T cells. Scale bar = 200 μm. g Percentage of CD8+ T cells in CD3+ infiltration cells isolated from tumors of 615 mice bearing MFC cells in the presence or absence of LSD1. The data are presented as the mean ± SD; n = 3; n.s, no significance, *P < 0.05; two-tailed unpaired Student’s t-test