Skip to main content
Fig. 3 | Molecular Cancer

Fig. 3

From: LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

Fig. 3

Inhibition of LSD1 downregulates PD-L1 gene levels in GC. a and b Expression of total PD-L1 (a) and membrane PD-L1 (b) in a panel of GC cell lines. c and d mRNA (c) and protein (d) expression of PD-L1 when BGC-823 cells were exposed to GSK2879552 for 5 days. e and f mRNA (e) and protein (f) expression of PD-L1 in BGC-823 and MGC-803 cells in the presence or absence of LSD1. g and h Morphology (g) and number (h) of polyvesicular corpuscles in BGC-823, MGC-803 cells in the presence or absence of LSD1. Scale bar = 2 µm (The data are presented as the mean ± SD; n = 4). i Expression of LSD1 and TSG101 in BGC-823, MGC-803 cells in the presence or absence of LSD1. The data are presented as the mean ± SD; n = 3; n.s, no significance, *P < 0.05; two-tailed unpaired Student’s t-test

Back to article page