Fig. 3
From: Targeting the RNA m6A modification for cancer immunotherapy
Inhibitors of m6A regulators in tumor cells indirectly augment T cell trafficking and decrease immunosuppression. A High expression in tumor cells of m6A regulators, such as FTO, ALKBH5, and others, leads to an immune-suppressed TME characterized by high expression of immune checkpoints [PD-1 and leukocyte immunoglobulin-like receptor B4 (LILRB4)], reduced infiltration, decreased cytotoxic function of CD8+ T cells, and enhanced infiltration of Treg cells and myeloid-derived suppressor cells (MDSCs). B Targeting FTO or ALKBH5 with specific inhibitors, such as CS1/2, Dac51, or ALK-04, or combining with ICBs, reverses the immunosuppressive TME by increasing the infiltration and cytotoxicity of CD8+ T cells and inhibiting the infiltration of Treg cells and MDSCs, thereby creating an immune-activated TME. Figure created with BioRender.com