Skip to main content

Table 1 Role of m6A modifications in remodeling the tumor microenvironment

From: Targeting the RNA m6A modification for cancer immunotherapy

Regulators

Cancer type

Up- or down-regulated in tumor cells

Function

References

METTL3

TGCT

Down-regulated

Positively correlates with infiltration of CD8+ T cells, CD4+ T cells, and NK cells

[69]

METTL3

CRC

Up-regulated

Negatively correlates with infiltration of CD8+ T cells;

Negatively correlates with IFN-γ, CXCL9, and CXCL10 secretion;

Negatively correlates with the response to anti-PD-1 treatment

[70]

METTL3

CC

Up-regulated

Positively correlates with the density of CD33+ MDSCs

[71]

METTL3

BC

Up-regulated

Negatively correlates with infiltration of CD8+ T cells, helper T cells, and activated NK cells; positively correlates with infiltration of M2 TAMs

[72]

METTL3

HCC

Up-regulated

Negatively correlates with infiltration of DCs

[73]

METTL3 HNRNPC

HNSCC

Up-regulated

Positively correlates with the infiltration of CD4 naive T cells, CD4 memory-activated T cells and eosinophils

[74]

METTL14

BC

Down-regulated

Positively correlates with infiltrating levels of CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and DCs; negatively correlates with Treg cells

[77]

METTL14

ccRCC

Up-regulated

Negatively correlates with infiltration of Treg cells

[78]

WTAP

GC

Up-regulated

Negatively correlates with T cell infiltration and T cell-related immune responses

[79]

WTAP

EC

Up-regulated

Positively correlates with both the immuno-inhibitors and immuno-stimulators infiltration, such as myeloid DCs, T cells, neutrophils, Treg cells, and macrophages

[80]

FTO

AML

Up-regulated

Positively correlates with immune evasion, and inhibits the cytotoxicity of T cells

[85]

ALKBH5

Melanoma

unknown

Positively correlates with Treg cell infiltration; ALKBH5 deletion enhances the efficacy of anti–PD-1 therapy

[88]

ALKBH5

ICC

unknown

Positively regulates PD-L1 expression in tumor cells and inhibits the expansion and cytotoxicity of T cells by PD-1/PD-L1 signaling

[89]

YTHDF2

LGG

unknown

Positively correlates with infiltration of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and DCs

[92]

YTHDF1

YTHDF2

NSCLC

Up-regulated

Positively correlates with tumor-infiltrating lymphocytes, including CD8+ T cells, FOXP3+ T cells, PD-1+ T cells, and CD45RO+ immune cells

[93]

YTHDF2

KIRC

Down-regulated

Positively correlates with infiltration of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and DCs

[94]

YTHDF1

GC

Up-regulated

Negatively correlates with CD4+ cells and CD8+ T cells; positively correlates with MDSCs

[96]

YTHDF1

BC

Up-regulated

Negatively correlates with infiltration of CD4+ cells, CD8+ T cells, activated NK, and monocytes; positively correlates with infiltration of M1 macrophages

[97]