Targeting the RNA m6A modification for cancer immunotherapy

Table 2 Specific inhibitors against m⁶A regulators

Targets	Inhibitors	Function	References
FTO	rhein	Inhibits FTO activity on m⁶A demethylation	[110,111,112,113]
	MO-I-500
	meclofenamic acid
	fluorescein
	R-2HG	Anti-leukemia and anti-glioma	[114]
	FB23/FB23-2	Inhibits the proliferation and promotes cell differentiation/apoptosis of human acute myeloid leukemia cells	[115]
	CS1/CS2	Inhibits cancer cell proliferation, cancer stem cell self-renewal and immune evasion	[85]
	Dac51	Promotes T cell response and enhances the anti-PD-1 therapy	[86]
ALKBH5	2-{[1-hydroxy-2-oxo-2-phenylethyl] sulfanyl} acetic acid, 4-{[furan-2- yl]methyl}amino-1,2-diazinane-3,6- dione	Suppresses the proliferation of leukemia cell lines (HL-60, CCRF-CEM, and K562)	[116]
ALKBH5	ALK-04	Inhibits the infiltration of Treg cells and MDSCs, enhances the anti-PD-1 therapy	[88]
METTL3/ME TTL14	STM2457	Prevents AML expansion and reduces the number of leukemia stem cells in vivo	[117]

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