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Fig. 4 | Molecular Cancer

Fig. 4

From: The N6-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p/PGF signalling pathway

Fig. 4

The m6A modification of circALG1 promoted CRC metastasis in SW480 cells. A MeRIP assays of m6A-modified circALG1 in SW480 cells. B-D Construction of an overexpression plasmid targeting the mutations at m6A modification sites of circALG1 (B), qRT-PCR detection of the circALG1 expression level (C), and MeRIP analysis of m6A-modification level of circALG1 (D). E Representative images and bar graphs of Transwell migration and invasion assays of cells with different circALG1 m6A modification levels. The results are presented as the mean ± s.d. and are representative of at least 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, #p > 0.05

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Molecular Cancer

ISSN: 1476-4598