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Fig. 4 | Molecular Cancer

Fig. 4

From: Reprogramming the tumor microenvironment by genome editing for precision cancer therapy

Fig. 4

Reprogramming TME intercellular communication via gene editing. Gene editing is used to reprogram TME intercellular communication, including communication between tumor cells and immune cells or between different immune cells. The former includes T cell–tumor cell, NK cell–tumor cell, and macrophage–tumor cell communication, while the latter includes T cell–DC and T cell–Treg communication. The application of gene editing in immune cell–tumor cell communication facilitates enhancement or restoration of the ability of immune cells to recognize tumor cells. In immune cell–immune cell communication, gene editing is mainly used to promote antigen presentation by DCs and inhibit the immunosuppressive activity of Tregs. As shown in the panels, ①-③ show communication between tumor and immune cells, and ④⑤ show communication between different immune cells

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