Table 2 Potential edited genes that regulate cells proliferation, differentiation or function in TME

CD8⁺T cell

Promote proliferation

IL-2Rα, IL-2Rβ, IL-4Rα, IL-7Rα, IL-10Rα, IL-10Rβ, IL-12R, IL-15Rα, GITR, HDAC1, NFAT1, NR4A1, SLAT, SUMO2, TL1A, DOCK8, TIS21, STAT6, TNFRSF4, TNFRSF8, TNFRSF9, TNFRSF25, CD25, CD4, CD62L, CD27, CD70

[16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37]

Inhibit proliferation

FOXP1, FOXO3, JNK2, VDR, IL-10R2, PD-1, TIM-3, CD38, CD160

[38,39,40,41,42,43,44,45,46]

Inhibit function

PD-1, TIM-3, LAG-3, CTLA-4, TIGIT, T-bet, BLIMP1, NFAT, BATF, VHL, FOXO1, FOXP1, SLAMF6, TCF1, NR4A1, TOX, FGL1, B7H3, CD73, CD39, CD244, CD160

[47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65]

CD4⁺T cell

Control differentiation

IL2Rα, IL-4R, IL-6R, IL-10R, IL-12R, IL-13R, IL-21R, IL-23R, IL-25R, STAT1, STAT4, STAT6, GATA3, PPARG, IKZF2, CXCR5, FOXO1, FOXP3, CD8α, CD103, USP22, BRD9, RNF20, IRF4, CIC, PRDM1, TBX21, SATB1, HIVEP2, HDAC6, BCL6

[66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86]

NK cell

Promote proliferation

IL-2, IL-4, IL-12, IL-10, IL-15, IL-18, IL-21, IL-15Rα, CD16A, KLF2, TNFRSF4

[87,88,89,90,91,92,93,94,95,96,97]

Inhibit proliferation

CD2

[98]

Enhance toxicity effect

NKG2D, TNFRSF9, GRAIL, CD16, CD244, NTB-A, CS1, SCF

[99,100,101,102,103,104]

Inhibit function

LAG-3, PD-1, TIM-3, TIGIT, KLRG1, KIR, NKG2A, CD96

[105,106,107,108,109]

TAF

Activate

IL-1R1, FGFR, GPER, TGFR, TNFR, GFs, VDR, NF-κB, JAK, STAT3, NLRP3, YAP, TAZ

[110,111,112,113,114,115,116,117,118]

Regulate immune microenvironment

TGFβ, CCL2, CCL5, CCL7, CCL16, CXCL1, CXCL2, CXCL8, CXCL12, G-CSF, LIF, IL-6, IL-11, IL-33, NOX4, M-CSF, PGE2

[110, 119,120,121,122,123,124,125,126,127]

Promote tumor growth, migration, invasion and epithelial-mesenchymal transformation

HGF, FGF1, PDGF, POSTN, OPN, CTGF, FOXF1, IL-17A, Cav1, FAP, α-SMA, FN1, VEGF, MMPs, MFAP5, ET-1

[122, 128,129,130,131,132,133,134,135,136,137,138,139,140,141,142]

Inhibit tumor growth

ISLR, WFDC1

[143, 144]

TAM

Polarize to M1

TLR, DNMT3b, JMJD1A, HDAC3, HDAC9, STAT1, NF-κB, IRF5, Notch signaling, ERK5, MGLL, IRF1, IRF5, IRF8

[145,146,147,148,149,150,151]

Polarize to M2

CSF-1R, CCR2, IL-1R, IL-4R, IL-10, IL-12R, IL-13R, IL-18R, GPR132, PRMT1, SMYD3, JMJD3, SIRT, BET, STAT3, STAT6, MYC, IRF3, IRF4, KLF4, PPARγ, COX-2, PI3Kγ

[146, 148, 152,153,154,155,156,157,158,159,160]