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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation

Fig. 5

The effect of C1QBP on wnt/β-catenin signaling pathway regulated by circMTCL1. a, Schematic diagram of functioning manner between C1QBP and wnt β-catenin pathway regulated by circMTCL1. b, Western blot assays showing the expression of β-catenin, p-β-catenin, GSK3β upon C1QBP silencing or overexpressing in TU212 and LCC cell. c, The migrated cell numbers were determined after ectopic or knockdown C1QBP in TU212 and LCC cells. Scale bars = 500 μm. d, CFA assays displaying the colony-forming abilities upon C1QBP silencing or overexpressing in TU212 and LCC cells. e, Co-IP and western blot assays demonstrating the association of C1QBP and β-catenin in TU212 cells without any intervention. f, co-IP and western blot assays confirming the association between C1QBP and β-catenin after overexpressing circMTCL1 in TU212 cells. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001

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Molecular Cancer

ISSN: 1476-4598