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Fig. 5 | Molecular Cancer

Fig. 5

From: The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma

Fig. 5

RIG-I overexpression reverses the protumorigenic capacity of ALKBH5. a Cell proliferation was detected after transfection with ALKBH5 and/or RIG-I for 3 days. b Colony formation assays were performed. c EdU assays were performed after transfection with ALKBH5 and/or RIG-I for 48 h. d, e Tumor volume and weight were measured in nude mouse xenograft models established using lentivirus-transduced cells. f, g, h Ki-67 and TUNEL staining was performed using tumor tissues from the xenograft model. Bar: 100 μm. Data are presented as the mean ± S.D. One-way ANOVA; *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598