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Fig. 8 | Molecular Cancer

Fig. 8

From: The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma

Fig. 8

AKLBH5 upregulation is negatively correlated with RIG-I and IFNα expression in HNSCC patients. a Representative images of immunohistochemical staining for ALKBH5, RIG-I, and IFNα on a TMA composed of 138 HNSCC tissues. b-d The correlations among ALKBH5 expression, RIG-I protein expression, and IFNα protein expression were detected and analyzed in a TMA with samples from 138 HNSCC patients. e A schematic showing the mechanism by which ALKBH5 upregulation promotes HNSCC progression and immune evasion by inhibiting RIG-I-mediated IFNα secretion via the IKKε/TBK1/IRF3 pathway, ultimately reducing immune-killing cell infiltration in the tumor microenvironment. Bar: 100 μm, Data information: Pearson correlation coefficient; *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598