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Fig. 2 | Molecular Cancer

Fig. 2

From: M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

Fig. 2

circMDK promotes cell proliferation, migration, invasion and impedes apoptosis in HCC cells. A Cell proliferation assays for Huh7 and Hep3B cells with silencing circMDK. **p < 0.01; ***p < 0.001. B Cell proliferation assays for HCCLM3 and SK-Hep-1 cells with overexpressing circMDK. **p < 0.01; ***p < 0.001. C Colony formation assays for Huh7 and Hep3B cells with silencing circMDK. ***p < 0.001. D Colony formation assays for HCCLM3 and SK-Hep-1 cells with overexpressing circMDK. **p < 0.01. E Cell migration analysis of Huh7 and Hep3B cells with silencing circMDK (top) and HCCLM3 and SK-Hep-1 cells with overexpressing circMDK (bottom). **p < 0.01. F Cell invasion analysis of Huh7 and Hep3B cells with silencing circMDK (top) and HCCLM3 and SK-Hep-1 cells with overexpressing circMDK (bottom). **p < 0.01. G Cell apoptosis analysis of Huh7 and Hep3B cells with silencing circMDK (left) and HCCLM3 and SK-Hep-1 cells with overexpressing circMDK (right). ***p < 0.001; **p < 0.01. Data are shown as mean ± SD of three independent experiments

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Molecular Cancer

ISSN: 1476-4598