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Fig. 4 | Molecular Cancer

Fig. 4

From: Long noncoding RNA TLNC1 promotes the growth and metastasis of liver cancer via inhibition of p53 signaling

Fig. 4

TLNC1 induces deregulation of the genes involved in cell proliferation and metastasis in hepatoma cells. a Heatmap of differentially expressed genes from HCCLM3 cells transfected with control shRNA or shRNA targeting TLNC1. Red indicates upregulated genes and blue indicates downregulated genes. b Functional annotation by KEGG and GO analysis revealed genes involved in p53 signaling pathway, cell cycle, and cell adhesion process. c Heatmap of differentially expressed genes upon TLNC1 knockdown enriched in p53 signaling pathway, cell cycle and focal adhesion process. d-e qRT-PCR results confirmed the differentially expressed genes selected from functional annotation analysis in indicated HCCLM3 (TLNC1 knockdown) and SK-Hep1 (TLNC1 overexpression) cells. The data are the means ± SEM and are representative of three independent experiments. **p < 0.01, ***p < 0.001

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