Fig. 4From: Long noncoding RNA TLNC1 promotes the growth and metastasis of liver cancer via inhibition of p53 signalingTLNC1 induces deregulation of the genes involved in cell proliferation and metastasis in hepatoma cells. a Heatmap of differentially expressed genes from HCCLM3 cells transfected with control shRNA or shRNA targeting TLNC1. Red indicates upregulated genes and blue indicates downregulated genes. b Functional annotation by KEGG and GO analysis revealed genes involved in p53 signaling pathway, cell cycle, and cell adhesion process. c Heatmap of differentially expressed genes upon TLNC1 knockdown enriched in p53 signaling pathway, cell cycle and focal adhesion process. d-e qRT-PCR results confirmed the differentially expressed genes selected from functional annotation analysis in indicated HCCLM3 (TLNC1 knockdown) and SK-Hep1 (TLNC1 overexpression) cells. The data are the means ± SEM and are representative of three independent experiments. **p < 0.01, ***p < 0.001Back to article page