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Fig. 7 | Molecular Cancer

Fig. 7

From: Long noncoding RNA TLNC1 promotes the growth and metastasis of liver cancer via inhibition of p53 signaling

Fig. 7

High levels of TLNC1 combined with low levels of p21 is associated with poor prognosis of liver cancer patients. a-b Kaplan-Meier curves for overall survival and disease-free survival of patients from the West China Hospital (WCH) dataset with high or low TLNC1 expression levels. c-d Kaplan-Meier curves for overall survival and disease-free survival of patients from the TCGA dataset with high or low TLNC1 expression levels. e-f Kaplan-Meier curves for overall survival and disease-free survival based on the combination of TLNC1 and p21 mRNA expression levels. Liver cancer patients were divided into three groups based on TLNC1 and p21 mRNA expression: group 1 (n = 29): high TLNC1 and low p21 expression; group 2 (n = 29): low TLNC1 and high p21 expression; group 3 (n = 14): low TLNC1 and p21 expression or high TLNC1 and p21 expression. g A schematic model showing the function of TLNC1 in regulating p53 signaling pathway. Elevated TLNC1 levels promote the nuclear export of p53 through strengthening the protein-protein interactions among p53, CRM1 and TPR. TLNC1 represses the transcription of a series of tumor suppressors, including p21, Bax and Maspin, meanwhile activates the transcription of genes associated with metastasis, such as Vimentin and MMP2, which ultimately contributes to the promotion of tumor growth and metastasis of hepatoma

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