Fig. 6

DZN and DSF significantly decrease paclitaxel resistance in NSCLC/PTX cells in vivo. A A schematic view of the establishment and treatment of NCI-H460/PTX xenograft mice. NCI-H460/PTX cells were subcutaneously injected into the right flank of BALB/c nude mice. Treatments were administered as indicated by the colored triangles (i.p., intraperitoneal). B The inhibitory effect of different treatments on relative tumor volume. C Images of tumors from NCI-H460/PTX xenograft mice. D The tumor inhibition rate (%) and tumor weight (mg) in the different groups. E Images of tumor sections after the TUNEL assay and statistical analysis of TUNEL-positive (apoptotic) cells. The photographs were taken at magnifications of × 200. Scale bar = 50 μm. F The expression levels of RAS/RAF pathway-related proteins in NCI-H460/PTX xenograft. G Representative immunohistochemistry of P-Erk1/2 in NCI-H460/PTX xenograft and statistical analysis of P-Erk1/2-positive cells. ^**p < 0.01, ^***p < 0.001, compared with control group. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, compared with the PTX group