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Fig. 7 | Molecular Cancer

Fig. 7

From: An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer

Fig. 7

JIB04 significantly decreases paclitaxel resistance in NSCLC/PTX cells in vivo. A A schematic view of the establishment and treatment of NCI-H460/PTX xenograft mice. NCI-H460/PTX cells were subcutaneously injected into the right flank of BALB/c nude mice. Treatments were administered as indicated by the colored triangles (i.p., intraperitoneal). B The inhibitory effect of the treatments on relative tumor volume, and images of tumors from NCI-H460/PTX xenograft mice. C The tumor inhibition rate (%) and tumor weight (mg) in the different treatment groups. D ALDH2 proteins expression levels in NCI-H460/PTX xenograft mice. E Representative immunohistochemistry of ALDH2 in NCI-H460/PTX xenograft and statistical analysis of ALDH2-positive cells. F Images of tumor sections after the TUNEL assay. The photographs were taken at magnifications of × 200. Scale bar = 50 μm. G The inhibitory effect of the different treatment on relative tumor volume, and images of tumors from the NCI-H460/PTX xenograft mice. **p < 0.01, ***p < 0.001, compared with control group. #p < 0.05, compared with the PTX group. &p < 0.05, &&p < 0.01, compared with the PTX + DZN group

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