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Fig. 8 | Molecular Cancer

Fig. 8

From: An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer

Fig. 8

Schematic diagram showing the mechanism of ALDH2-mediated PTX resistance and potential treatment strategies. A Regulation of ALDH2 by EHMT2 and NFYA significantly decreases the efficacy of paclitaxel in NSCLC/PTX resistant cells. B Epigenetic downregulation of ALDH2 by JIB04 reverses paclitaxel resistance. C Pharmacological inhibition of ALDH2 by DZN or DSF reverses paclitaxel resistance

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Molecular Cancer

ISSN: 1476-4598