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Fig. 5 | Molecular Cancer

Fig. 5

From: AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p

Fig. 5

Correlations between c-MYC, AP4, MDC1 and miR-22-3p expression in primary CRCs. A Relative expression of the indicated mRNAs detected in expression profiles from patient-derived normal mucosa and tumor tissue deposited in the TCGA-COAD and GEO databases. B Scatter plots of pair-wise comparisons of mRNA expression of the indicated genes in TCGA-COAD samples. C Heat maps of associations between c-MYC, AP4, MIR22HG and MDC1 expression and CMS/CRIS subtypes in the indicated patient cohorts. D RNAs were ranked in descending order according to Pearson correlation coefficient r with MIR22HG expression for the indicated datasets. The positions of MDC1, c-MYC and AP4 expression in the ranked lists are indicated

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