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Table 2 The functions and mechanisms of Wnt-associated circRNAs in cancer

From: The functional roles of the circRNA/Wnt axis in cancer

Category

Type

circRNA

Role

Functions

Targeted molecule

Refs

Digestive tumors

Esophageal cancer

circRNA_100367

Oncogene

EMT, proliferation, migration, and radioresistance

miR-217, and Wnt3

[192]

 

Esophageal cancer

cir-ITCH

Tumor suppressor

Cell cycle, and cell proliferation

miRNA, Wnt

[193]

 

Gastric cancer

circ0005654

Oncogene

Proliferation, migration, and invasiveness

miR-363, SP1, Wnt, and β-catenin

[159]

 

Gastric cancer

circRNA _ asap2

Oncogene

Proliferation, migration, invasion, and cell apoptosis

Wnt, and β-catenin

[194]

 

Gastric cancer

circ-SFMBT2

Oncogene

Proliferation, migration, invasion, cell apoptosis, and oxidative stress

miR-885-3p, CHD7, Wnt, and β-catenin

[195]

 

Gastric cancer

circCNIH4

Tumor suppressor

Proliferation, migration, invasion, and cell apoptosis

DKK2. FRZB, Wnt, and β-catenin

[196]

 

Gastric cancer

circ_SMAD4

Oncogene

Proliferation, and cell apoptosis

miR-1276, CTNNB1, Wnt, and β-catenin

[73]

 

Gastric cancer

circRNA_0044516

Oncogene

Proliferation, and cell apoptosis

miR-149, Wnt1, and β-catenin

[197]

 

Gastric cancer

cir-ITCH

Tumor suppressor

Cell proliferation, migration, and invasion

miR-17, Wnt, and β-catenin

[160]

 

Gastric cancer

circ_0001649

Tumor suppressor

Proliferation, migration, invasion, and cell apoptosis

miR-20a, ERK, and Wnt/β-catenin

[198]

 

Gastric cancer

circHIPK3

Oncogene

Proliferation, and migration

Wnt1, and β-catenin

[161]

 

Colorectal cancer

circ_0038718

Oncogene

Cell proliferation, migration, and invasion

miR-195-5p, Axin2, and Wnt/β-catenin

[199]

 

Colorectal cancer

circ_0026628

Oncogene

Cell proliferation, migration, and stemness

miR-346, FUS protein, SP1, Wnt/β-catenin, and Sox2

[200]

 

Colorectal tumor

cis-HOX

Oncogene

Self-renewal, tumorigenesis, and metastatic capacities of TICs

FZD3, Wnt/β-catenin, and KSRP

[201]

 

Colorectal cancer

circRASSF2

Oncogene

Cell proliferation, migration, invasion, and cell apoptosis

miR-195-5p, FZD4, Wnt, and β-catenin

[162]

 

Colorectal cancer

circSMARCA5

Tumor suppressor

Cell proliferation, migration, and invasion

miR-552, Wnt, and YAP1

[202]

 

Colorectal cancer

circ_0082182

Oncogene

Cell proliferation, cell cycle, apoptosis, and metastasis

miR-411, miR-1205, and Wnt/β-catenin

[163]

 

Colorectal cancer

circAGFG1

Oncogene

Cell proliferation, migration, stemness, and apoptosis

mir-4262, miR-185-5p, YY1, CTNNB1, Wnt, and β-catenin

[203]

 

Colorectal cancer

circ-PRKDC

oncogene

5-FU resistance, cell proliferation, and invasion

FOXM1, miR-375, Wnt, and β-catenin

[164]

 

Colorectal cancer

circ5615

Oncogene

Cell proliferation, cell cycle, and invasion

miR-149-5p, TNKS, Wnt, and β-catenin

[165]

 

Colorectal cancer

circ-ABCC1

Oncogene

Cell stemness, sphere formation, and metastasis

Wnt

[204]

 

Colorectal cancer

circCCT3

Oncogene

Cell invasion, and apoptosis

miR-613, Wnt3, miR-613, and VEGFA

[166]

 

Colorectal cancer

circ _ 0009361

Tumor suppressor

Cell proliferation, migration, invasion, and EMT

miR-582, Wnt, and β-catenin

[205]

 

Colorectal cancer

circ _ 0005075

Oncogene

Cell proliferation, migration, and invasion

Wnt, and β-catenin

[167]

 

Colorectal cancer

circMTO1

Tumor suppressor

Cell proliferation, and invasion

Wnt, and β-catenin

[70]

 

Colorectal cancer

circ _ 0000523

Tumor suppressor

Cell proliferation, and apoptosis

miR-31, Wnt, and β-catenin

[206]

 

Colorectal cancer

circRNA_100290

Oncogene

Cell proliferation, migration, and invasion

miR-516b, FZD4, Wnt, and β-catenin

[168]

 

Colorectal cancer

cir-ITCH

Tumor suppressor

Cell proliferation

Wnt, and β-catenin

[207]

 

Liver cancer

circRNA-SORE

Oncogene

Sorafenib resistance, and apoptosis.,

Wnt, and β-catenin

[71]

 

Liver cancer

circ_0004018

Tumor suppressor

Cell proliferation, and migration

miR-626, DKK3, Wnt, and β-catenin

[169]

 

Liver cancer

circ-ITCH

Tumor suppressor

Cell proliferation, and apoptosis

Wnt, β-catenin, c-Myc, and CyclinD1

[174, 208]

 

Liver cancer

circ_0003418

Tumor suppressor

Cell proliferation, migration, invasion, and cisplatin resistance

Wnt, and β-catenin

[170]

 

Liver cancer

circZKSCAN1

Tumor suppressor

Cell stemness

FMRP, CCAR1, and Wnt

[171]

 

Liver cancer

cZNF292

Oncogene

Cell proliferation, and cell cycle

Wnt, β-catenin, and SOX9

[209]

 

Liver cancer

circβ-catenin

Oncogene

Cell growth, cell cycle, migration, and invasion

Wnt, and β-catenin

[210]

 

Liver cancer

circZFR

Oncogene

Cell proliferation and EMT

Wnt, and β-catenin

[172]

 

Liver cancer

circ_0067934

Oncogene

Cell proliferation, migration, invasion, and apoptosis

miR-1324, FZD5, and β-catenin

[173]

 

Liver cancer

circ-ITCH

Tumor suppressor

  

[174]

 

Pancreatic cancer

circ_0030167

Tumor suppressor

Cell invasion, migration, proliferation and stemness

miR-338-5p, Wip1, Wnt 8, and β-catenin

[211]

Respiratory system tumors

Lung cancer

circ-PGC

Oncogene

Cell viability, colony formation, cell migration, invasion, and glycolysis metabolism

miR-532-3p, FOXR2, Wnt, and β-catenin

[212]

 

Lung cancer

circ-ZNF124

Oncogene

Cell proliferation, invasion, apoptosis, and cycle arrest

miR-498, YES, Wnt, and β-catenin

[213]

 

Lung cancer

circ-BIRC6

Oncogene

Cell proliferation, migration and invasion, and apoptosis

miR-4491, Wnt2B, and β-catenin

[214]

 

Lung cancer

circ_0067934

Oncogene

Cell proliferation, migration, invasion, and apoptosis

miR-1182, Klf8, Wnt, and β-catenin

[215]

 

Lung cancer

circ_000984

Oncogene

Cell proliferation, migration, invasion, and EMT

Wnt, and β-catenin

[175]

 

Lung cancer

circ_001569

Oncogene

Cell proliferation

Wnt, and β-catenin

[176]

 

Lung cancer

circ_0043256

Oncogene

Cell proliferation, and apoptosis

miR-1252, ITCH, and Wnt

[216]

 

Lung cancer

circ-SOX4

Oncogene

Cell proliferation, invasion, and migration

miR-1270, PLAGL2, and Wnt

[69]

 

Lung cancer

circ_0001946

Oncogene

Cell proliferation

miR-135a-5p, SIRT1, Wnt, and β-catenin

[177]

 

Lung cancer

circ_0018414

Tumor suppressor

Cell proliferation, stemness, and apoptosis

miR-6807-3p, DKK1, Wnt, and β-catenin

[178]

 

Lung cancer

circ_0006427

Tumor suppressor

Cell proliferation, migration, and invasion

miR-6783-3p, DKK1, Wnt, and β-catenin

[179]

 

Lung cancer

circ_0007059

Tumor suppressor

Cell proliferation, apoptosis, and EMT

miR-378, Wnt, and β-catenin

[180]

 

Lung cancer

cir-ITCH

Tumor suppressor

Cell proliferation

Wnt, and β-catenin

[181]

Nervous system neoplasms

Glioma

circ_0001730

Oncogene

Cell proliferation, and migration

Sp1, miR-326, Wnt7B, and β-catenin

[182]

Glioma

circKIF4A

Oncogene

Colony formation, migration, invasion, and apoptosis

miR-139-3p, Wnt, and β-catenin

[217]

Glioma

circ_0000177

Oncogene

Cell proliferation, and invasion

miR-638, FZD7, and Wnt

[183]

Glioma

cZNF292

Oncogene

Cell proliferation, cell cycle, and angiogenic potential

Wnt, and β-catenin

[218]

Genitourinary tumors

Prostate cancer

cir-ITCH

Tumor suppressor

Cell viability, and invasion

miR-17, Wnt, β-Catenin, PI3K, AKT, and mTOR

[219]

Ovarian cancer

circABCB10

Oncogene

Cell proliferation, invasion, and cell apoptosis

miR-1271, Capn4, Wnt, and βcatenin

[220]

Ovarian cancer

circPLEKHM3

Tumor suppressor

Cell growth, and migration

miR-9, BRCA1, DNAJB6, KLF4, Akt1, Wnt, and β-catenin

[184]

Endometrial carcinoma

circ_0109046

Oncogene

Cell proliferation, aggressiveness, and apoptosis

miR105, SOX9, Wnt, and β-catenin

[185]

Endometrial carcinoma

circ_0002577

Oncogene

Cell proliferation, migration, and invasion

miR-197, CTNND1, Wnt, and β-catenin

[186]

Cervical cancer

circSAMD11

Oncogene

Cell proliferation, migration, invasion, and apoptosis

miR-503, SOX4, Wnt, and β-catenin

[221]

Blood system cancers

Acute myeloid leukemia

circ_0121582

Tumor suppressor

Cell proliferation, and cell cycle

miR-224, GSK3β, Wnt, and β-catenin

[222]

Chronic lymphocytic leukemia

circ-CBFB

Oncogene

Cell proliferation, cell cycle, and apoptosis

miR-607, FZD3, Wnt, and β-catenin

[223]

Diffuse large B-cell lymphoma

circ-APC

Tumor suppressor

Cell viability, and cell cycle

Wnt, β-catenin, TET1, and miR-888

[224]

Musculoskeletal system tumors

Osteosarcoma

circUBAP2

Oncogene

Cell proliferation, migration, invasion, apoptosis, and cisplatin resistance

miR-506-3p, SEMA6D, Wnt, and β-catenin

[225]

Osteosarcoma

circMYO10

Oncogene

Cell proliferation, and emt

miR-370-3p, RUVBL1, Wnt, and β-catenin

[63]

Osteosarcoma

circ_0002052

Tumor suppressor

Cell proliferation, migration, invasion, and apoptosis

miR1205, APC2, Wnt, and β-catenin

[187]

Endocrine system tumors

Thyroid cancer

circRNA_102171

Oncogene

Cell proliferation, migration, invasion, and apoptosis.

CTNNBIP1, β-catenin, TCF3, TCF4, LEF1 complex, Wnt, and β-catenin

[226]

Thyroid cancer

circRNA_NEK6

Oncogene

Cell growth, and invasion

FZD8, Wnt, and miR-370-3p

[227]

Thyroid cancer

circ-ITCH

Tumor suppressor

Cell proliferation, invasion, and apoptosis

miR-22-3p, CBL, and β-catenin

[188]

Other systems tumors

Breast cancer

circ-EIF6

Oncogene

Cell proliferation, migration, and invasion

MYH9, Wnt, β-catenin, and EIF6-224aa

[189]

 

Breast cancer

circARL8B

Oncogene

Cell viability, migration, invasion, and fatty acid metabolism

miR-653-5p, PGE2, PI3K, AKT, GSK-3β, Wnt, and β-catenin

[228]

 

Breast cancer

circABCC4

Oncogene

Cell viability, migration, invasion, and apoptosis

miR-154-5p, NF-κB, Wnt, and β-catenin

[229]

 

Breast cancer

circ-ITCH

Tumor suppressor

Cell proliferation, invasion, and metastasis

miR-214, miR-17, ITCH, Wnt, and β-catenin

[190]

 

Breast cancer

circRNA_069718

Oncogene

Cell proliferation, and invasion

Wnt, and β-catenin

[191]

 

Breast cancer

circFAT1

Oncogene

Cell apoptosis, migration, invasion, and oxaliplatin resistance

miR-525-5p, SKA1, Notch, and Wnt

[230]

 

Melanoma

circ_0119872

Oncogene

Cell proliferation, and angiogenesis

miR-622, G3BP1, Wnt, β-catenin, and mTOR

[231]

 

Melanoma

circ-GLI1 (circ_0027247)

Oncogene

Cell metastasis, and angiogenesis

p70S6K2, Hedgehog, GLI1, Cyr61, Wnt, and β-catenin

[232]

 

Melanoma

circ_0084043

Oncogene

Cell proliferation, migration, invasion, and apoptosis

miR-429, and homolog 2, Wnt, and β-catenin

[233]