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Fig. 7 | Molecular Cancer

Fig. 7

From: The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis

Fig. 7

Schematic diagram illustrates the mechanism of circHMGB2 relieves the inhibition of the downstream molecule CARM1 by sponging miR-181a-5p, which induces a reduction in the HDAC3 levels. Then, STAT1 deacetylation is inhibited, thereby reducing the phosphorylation of STAT1 and inhibiting IFN-γ signal transduction. Subsequently, the expression of IFN-activated genes, including CXCL10, ISG15, IL18, IFIT1, CCL5 and IFR7, were inhibited. Those drive immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas

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Molecular Cancer

ISSN: 1476-4598