The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis

Table 1 Correlations between circRNA HMGB2 and clinical characteristics in 120 NSCLC patients

Clinicopathological parameters	No. of cases	CircHMGB2 expression level		P value
Clinicopathological parameters	No. of cases	Low	High	P value
Age
≥60	53	28	25
<60	67	32	35	0.581
Gender
Male	67	36	31
Female	53	24	29	0.358
Smoking history
Smokers	54	24	30
Nonsmokers	66	36	30	0.271
Histological type
Adenocarcinoma	78	41	37
Squamous	42	19	23	0.444
Tumor stage
I–II	72	31	41
III–IV	48	29	19	0.062
Lymph node metastasis
Yes	50	19	31
NO	70	41	29	0.026
Tumor size
>2 cm	55	21	34
≤2 cm	65	39	26	0.017
Differentiation
Well and moderate	57	23	34
Poor	63	37	26	0.044

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