The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis

Table 2 Univariate and multivariate analyses of factors associated with overall survival

Factors	OS
	Univariate			Multivariate
	HR	95% CI	P value	HR	95% CI	P value
Age(≥60 VS <60)	0.856	0.683–1.073	0.178			NA
Gender(Male VS Female)	0.914	0.726–1.151	0.446			NA
Smoking history (smokers VS Nonsmokers)	0.946	0.755–1.186	0.631			NA
Histological type (adenocarcinoma VS squamous)	1.082	0.676–1.733	0.741			NA
Tumor stage (III–IV VS I–II)	0.79	0.630–0.991	0.041	0.692	0.544–0.882	0.003
Lymph node metastasis (Yes VS No)	0.716	0.571–0.898	0.004	0.735	0.581–0.929	0.01
Tumor size (>2 cm VS ≤2 cm)	0.732	0.582–0.919	0.007	0.811	0.639–1.030	0.086
Differentiation (poor VS well and moderate)	0.75	0.597–0.943	0.014	0.664	0.517–0.851	< 0.001
CircHMGB2 expression (High vs. Low)	0.709	0.562–0.894	0.004	0.600	0.459–0.783	<0.001

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