The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis

Table 3 Univariate and multivariate analyses of factors associated with cumulative recurrence

Factors	OS
	Univariate			Multivariate
	HR	95% CI	P value	HR	95% CI	P value
Age(≥60 VS <60)	0.957	0.773–1.185	0.687			NA
Gender(Male VS Female)	0.931	0.750–1.156	0.518			NA
Smoking history (smokers VS Nonsmokers)	0.919	0.743–1.138	0.44			NA
Histological type (adenocarcinoma VS squamous)	0.985	0.629–1.544	0.949			NA
Tumor stage (III–IV VS I–II)	0.77	0.622–0.955	0.017	0.68	0.540–0.856	0.001
Lymph node metastasis (Yes VS No)	0.722	0.582–0.895	0.003	0.749	0.598–0.939	0.012
Tumor size (>2 cm VS ≤2 cm)	0.778	0.627–0.965	0.022	0.854	0.681–1.070	0.17
Differentiation (poor VS well and moderate)	0.782	0.630–0.970	0.025	0.711	0.564–0.896	0.004
CircHMGB2 expression (High vs. Low)	0.713	0.573–0.888	0.002	0.617	0.479–0.795	<0.001

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