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Table 1 Elements of hedgehog pathway signal transduction

From: Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives

Gene

Full name of gene

Functions

Ref

Shh, Ihh, Dhh

Hedgehog ligand

Positive regulator of the Hh pathway

[1]

Ptch1

Patched 1

Negative regulator of the Hh pathway

[1]

Smo

Smoothened

Positive regulator of the Hh pathway

[33]

Sufu

Suppressed fusion protein

Negative regulator of the Hh pathway

[34]

Gli1, Gli2, Gli3

Glioma-associated oncogene 1, 2 and 3

Positive or negative regulator of the Hh pathway

[24]