Table 2 Dysregulation of circRNAs related to the hedgehog pathway in cancer

circSmo

Proliferation (+)

Encodes Smo-193a.a.

Smo

Glioblastoma

Up

[43]

circDGKB

Proliferation (+);

Migration (+);

Invasion (+);

Apoptosis (−)

As miR-873 sponge

Gli1

Neuroblastoma

Up

[86]

circZNF609

Proliferation (+);

Migration (+);

Invasion (+);

Apoptosis (−)

As miR-15a-5p/15b-5p sponge

Gli2

Hepatocellular carcinoma

Up

[87]

circZNF609

Migration (+)

As microRNA-150 sponge

Gli1

Colorectal cancer

Up

[88]

circSMO742

Proliferation (+);

Migration (+);

Apoptosis (−)

As miR-338-3p sponge

Smo

Glioma

Up

[89]

circ-STAT3

Proliferation (+);

Migration (+);

Invasion (+);

Stemness (+)

As miR-29a/b/c-3p sponge

Gli2

Hepatoblastoma

Up

[90]

circ_0036412

Proliferation (+)

As miR-579-3p sponge

Gli2

Hepatocellular carcinoma

Up

[91]

circDCAF6

Proliferation (+);

Stemness (+)

As miR-616-3p sponge

Gli1

Breast cancer

Up

[92]

circGli1

Migration (+);

Invasion (+)

Interacts with p70S6K2 protein

Gli1

Melanoma

Up

[93]

circIPO11

Proliferation (+)

Interacts with TOP1 protein

Gli1

Hepatocellular carcinoma

Up

[94]