Table 3 Dysregulation of microRNAs related to the hedgehog pathway in cancer

miR205HG

Proliferation (−);

Migration (−);

Invasion (−)

Shh

Esophageal adenocarcinoma

Down

[100]

miR-132

Proliferation (−);

Invasion (−)

Gli1

Glioma

Down

[101]

miRNA-326

Proliferation (−); Apoptosis (+)

Smo

Glioma;

Chronic myeloid leukemia

Down

[102, 103]

miR-361-3p

Proliferation (−);

Gli1, Gli3

Retinoblastoma

Down

[104]

miR-338-3p

Proliferation (−); Apoptosis (+)

Smo

Colorectal carcinoma

Down

[105]

miR-338-3p

Migration (−); Invasion (−)

Smo

Hepatocellular carcinoma

Down

[106]

miR-182-5p

Proliferation (−)

Gli2

Lung adenocarcinoma

Down

[107]

miR-1271

Proliferation (−); Apoptosis (+)

Smo

Multiple myeloma

Down

[108]

miR-506-3p

Migration (−);

Apoptosis (+)

Shh

Non-small-cell lung cancer

Down

[109]

miR-873-5p

Proliferation (−); Apoptosis (+)

Gli1

Gastric cancer

Down

[110]

miR-324-3p

Proliferation (−);

Invasion (−);

Apoptosis (+)

Gli3

Nasopharyngeal carcinoma

Down

[111]

miR-218

Apoptosis (+)

Smo

Gastric cancer

Down

[112]

miR-636

Proliferation (−);

EMT (−)

Gli2

Ovarian cancer

Down

[113]

miR-506

Proliferation (−); Apoptosis (+)

Gli3

Cervical cancer

Down

[114]

miR-7-5p

Proliferation (−);

Migration (−); Invasion (−)

Gli3

Bladder cancer

Down

[115]

miR-7-5p

Proliferation (−);

Invasion (−)

Smo

Gastric cancer

Down

[116]

miR-124

Proliferation (−)

Gli2

Glioma

Down

[117]

miR-150

Proliferation (−)

Gli1

Esophageal carcinoma

Down

[118]

–

Sufu

Chronic lymphocytic leukemia

Down

[119]

Proliferation (−);

Invasion (−);

EMT (−);

Stemness (−)

Gli2

Gastric cancer

Down

[120]

Proliferation (−);

Apoptosis (+)

Gli2

Osteosarcoma

Down

[121]

miR-212

Proliferation (+);

Migration (+);

Invasion (+)

Ptch1

Pancreatic ductal adenocarcinoma;

Non-small cell lung cancer

Up

[122, 123]

miR-150

Proliferation (+);

Migration (+);

EMT (+)

Sufu

Gastric cancer

Up

[124]

miR-9

Proliferation (+)

Ptch1

Glioblastoma

Up

[125]

Proliferation (+);

Invasion (+)

Sufu

Bladder cancer

Up

[126]

Migration (+);

Invasion (+);

Sufu

Lung adenocarcinoma

Up

[127]

Proliferation (+);

Migration (+);

Invasion (+)

Hhip

Glioblastoma

Up

[128]