Table 4 Dysregulation of lncRNAs related to the hedgehog pathway in cancer

LINC-PINT

Stemness (−)

As miR-425-5p sponge

Ptch1

Laryngeal carcinoma

Down

[138]

DIO3OS

Proliferation (−);

Migration (−); Invasion (−); Apoptosis (+)

As miR-328 sponge

Hhip

Hepatocellular carcinoma

Down

[139]

Apoptosis (+)

As miR-378a-5p sponge

Sufu

Triple-negative breast cancer

Down

[140]

Proliferation (−);

Migration (−); Invasion (−)

As miR-197-3p sponge

Sufu

Breast cancer

Down

[141]

LOC101930370

Proliferation (+);

Migration (+);

Invasion (+)

As miR-1471 sponge

Shh

Breast cancer

Up

[142]

TUG1

Proliferation (+)

As miR-132 sponge

Shh

Hepatocellular carcinoma

Up

[143]

LINC01510

Proliferation (+);

Migration (+); Invasion (+)

As miR-335 sponge

Shh

Papillary thyroid carcinoma

Up

[144]

LINC01123

Proliferation (+);

Migration (+);

Invasion (+)

As miR-516b-5p sponge

Gli1

Osteosarcoma

Up

[145]

NEAT1

Proliferation (+);

Migration (+);

Invasion (+);

Apoptosis (−)

As miR-503 sponge

Smo

Hepatocellular carcinoma

Up

[146]

Proliferation (+);

Migration (+);

Invasion (+);

EMT (+);

Stemness (+)

As miR-330-5p sponge

Smo

Hepatocellular carcinoma

Up

[147]

BCAR4

Migration (+);

Invasion (+)

Interacts with PNUTS and SNIP1 proteins

Gli2

Breast cancer

Up

[148]

LINC01426

Proliferation (+);

Migration (+);

EMT (+)

Interacts with USP22 protein

Shh

Lung adenocarcinoma

Up

[149]

lncHDAC2

Proliferation (+);

Stemness (+)

Interacts with HDAC2 protein

Ptch1

Hepatocellular carcinoma

Up

[150]

LINC01106

Proliferation (+);

Migration (+);

Stemness (+)

Interacts with FUS protein

Gli1, Gli2

Colorectal cancer

Up

[151]

Proliferation (−);

Migration (−); Invasion (−);

Apoptosis (+)

Interacts with HuR protein

Hhip

Hepatocellular carcinoma

Down

[152]

Stemness (+)

Regulates Gli2 transcription

Gli2

Renal cell carcinoma

Up

[153]