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Fig. 1 | Molecular Cancer

Fig. 1

From: Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer

Fig. 1

Functional characteristics of cultured TEC. A Study design. PCa, prostate cancer; NEC, normal endothelial cells; TEC, tumor endothelial cells. B Representative immunofluorescence staining (CD31 and VE-Cadherin) of NEC and TEC. C 3H-thymidine incorporation assay with NEC and TEC cultivated in ECM or ECM + 2% FCS (mean +—SEM; n = 4, p < 0.001). D Micrographs (left) and quantification (right) of NEC and TEC migration in scratch wound assay (mean +—SEM; n = 4, p < 0.001). E Quantification of cell area in TEC and NEC (mean +—SEM; n = 4, p < 0.01) F Quantification of nucleus area in TEC and NEC (mean +—SEM; n = 4, p < 0.01). 1G. % nucleus area/cell in TEC and NEC (n = 4). H Quantification of continuous versus discontinuous junctions (junctional length, % of total junctional length) in TEC and NEC (n = 4)

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Molecular Cancer

ISSN: 1476-4598