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Fig. 2 | Molecular Cancer

Fig. 2

From: Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer

Fig. 2

Bulk RNA-sequencing identified novel TEC markers. A Heatmap analysis and hierarchical clustering of the top 20 most up-and downregulated genes. Color-scale: red is higher expressed, blue is lower expressed. B Horizontal bar graphs representing the top 10 differentially expressed pathways as assessed by gene set enrichment analysis. C Micrographs of immunohistochemistry probing PLAC9. Note the high expression levels of PLAC9 in the tumor vasculature. D Micrographs of immunohistochemistry probing VDR. Note the high expression levels of VDR in the tumor vasculature. E Micrographs of immunohistochemistry probing PTGIR. Note the high expression levels of PTGIR in the tumor vasculature. F Representative immunofluorescence staining (CD31 and VDR) of NEC and TEC

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Molecular Cancer

ISSN: 1476-4598