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Fig. 4 | Molecular Cancer

Fig. 4

From: Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer

Fig. 4

Single-cell catalogue of the prostate tumor microenvironment. A Graphical representation of the experimental design. B t-SNE analysis of 16,529 freshly-isolated PCa TME cells. C Top panel: t-SNE plots color-coded for the indicated marker genes. Bottom panel: violin plots quantifying the expression of the indicated gene. Note, the numbers on the x-axis correspond to the cluster numbers shown in Fig. 4B. D Dendrogram visualization of hierarchical clustering analysis on gene signature correlations of highly variable genes. Note, the dots on the x-axis are color-coded, as in Fig. 4B. The order is the same as in Fig. 4E. E Heatmap analysis of the top 5 marker genes of all subtypes in the PCa TME. F Left panel: horizontal bar graphs indicating the relative composition of the TME cells across patients. Right panel: horizontal bar graphs indicating the relative cell composition in tumor and benign samples

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Molecular Cancer

ISSN: 1476-4598