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Fig. 2 | Molecular Cancer

Fig. 2

From: circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop

Fig. 2

circEXOC6B inhibits the growth of CRC cells in vitro and in vivo. A The expression of circEXOC6B in SW620 and HCT116 after transfected with siRNAs or a circEXOC6B overexpression vector. B CCK8 and C EdU assays indicated that the lower circEXOC6B levels promoted the proliferation of CRC cells while the higher circEXOC6B levels inhibited the proliferation. Scale: 50 μm. D Colony formation assay demonstrated that knockdown of circEXOC6B expression promoted the clonogenicity of SW620 and HCT116 while overexpression of circEXOC6B suppressed cancer cell clonogenicity. E Flow cytometry showed that the decreased circEXOC6B levels reduced the 5-FU-induced apoptosis of CRC cells, whereas the elevated circEXOC6B levels had the opposite effect

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Molecular Cancer

ISSN: 1476-4598