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Fig. 6 | Molecular Cancer

Fig. 6

From: MARCKSL1–2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b

Fig. 6

MARCKSL1–2 affects DTX resistance of LAD cells by regulating HDAC1/miR-200b axis. H1299 cells were transfected with shCtrl, shMARCKSL1–2#1, shMARCKSL1–2#1 + sh/HDAC1 or shMARCKSL1–2#1 + miR-200b mimics. H199/DTX cells were transfected with pcDNA3.1, pcDNA/MARCKSL1–2, pcDNA/MARCKSL1–2 + pcDNA/HDAC1 or pcDNA/MARCKSL1–2 + miR-200b inhibitor. Then, rescue assays were conducted on these groups of cells. a-d. Colony formation and EdU assays detected the proliferation of indicated H1299 and H1299/DTX cells. e-h. Flow cytometry analyses and TUNEL assays examined the apoptosis of indicated H1299 and H1299/DTX cells. **P < 0.01. n.s.: no significance

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Molecular Cancer

ISSN: 1476-4598