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Fig. 2 | Molecular Cancer

Fig. 2

From: Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1

Fig. 2

CircEIF4G3 overexpression attenuates GC growth and metastasis. (A) Cell counting assays for control and circEIF4G3 overexpressing GC cells. (B) The impact of circEIF4G3 overexpression on GC cell proliferation was determined by cell colony formation assay. (C-D) Transwell migration (C) and matrigel invasion assays (D) for control and circEIF4G3 overexpressing GC cells. (E–F) Flow cytometry analyses of cell apoptosis and cell cycle distribution in control and circEIF4G3 overexpressing groups. Data are shown as means ± SD (n = 3). (G-H) The volume and weight of subcutaneous xenograft tumors from mice injected with control and circEIF4G3 overexpressing GC cells (n = 5 mice/group). (I) HE staining and immunohistochemical staining of Ki-67 in mouse xenograft tumors with or without circEIF4G3 overexpression. *P < 0.05, **P < 0.01, ***P < 0.001; Scale bar = 100 μm

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