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Fig. 7 | Molecular Cancer

Fig. 7

From: Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1

Fig. 7

Proposed model for the roles and mechanisms of circEIF4G3 in GC progression. CircEIF4G3 destabilizes δ-catenin protein by enhancing TRIM25-mediated ubiquitin degradation and functions as a miRNA sponge to modulate miR-4449/SIK1 axis, which synergistically leads to the inactivation of β-catenin signaling and the inhibition of GC progression

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Molecular Cancer

ISSN: 1476-4598