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Fig. 11 | Molecular Cancer

Fig. 11

From: Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway

Fig. 11

Proposed model for the potential function of circPOLR2A in cRCC progression. In the nucleus, circPOLR2A was derived from exons 9 and 10 of the POLR2A gene by backsplicing. After export to the cytoplasm, circPOLR2A interacted with UBE3C and PEBP1 proteins, and formed a circPOLR2A/UBE3C/PEBP1 protein-RNA ternary complex, which facilitated the ubiquitination and degradation of PEBP1 and further activated ERK signaling in cRCC progression. Furthermore, circPOLR2A could be modified by m6A, and the m6A reader YTHDF2 inhibited circPOLR2A expression in cRCC

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Molecular Cancer

ISSN: 1476-4598