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Fig. 6 | Molecular Cancer

Fig. 6

From: Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway

Fig. 6

CircPOLR2A exerted its biological functions by inhibiting PEBP1 expression in cRCC cells. a, b Cell apoptosis was determined after cell transfection. 6a, 786O cells; 6b, Caki1 cells. c, f Transwell assay in rescue experiments. 6c, the effect of circPOLR2A knockdown in 786O cells could be counteracted by PEBP1 inhibition; 6f, the role of circPOLR2A overexpression in Caki1 cells could be rescued by PEBP1 overexpression. Scale bar, 40 μm. d, g Wound healing assay for rescue experiments. Scale bar, 100 μm. e, h Statistical analysis of the cell migration and invasion assays

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Molecular Cancer

ISSN: 1476-4598