Fig. 1

Expression profiles of circRNAs in human CRC and adjacent normal tissues. A Distribution of the identified circRNAs on human chromosomes. X-axis, the number of each chromosome; Y-axis, the number of circRNAs. B Circos plot depicting the distribution of circRNAs on human chromosomes. The outermost layer was a chromosome map of the human genome. The inner circles from outside to inside corresponded to distribution and expression of identified circRNAs on the chromosomes, distribution and expression of significantly expressed circRNAs, respectively. C Composition of the identified circRNAs in terms of genomic origin. D A cluster heap map presented the significantly dysregulated circRNAs in human CRC tissues relative to adjacent normal tissues. The red and blue strips represent high and low expression, respectively. CircEZH2 was marked in red. Scatter plot (E) and Volcano plot (F) of differentially expressed circRNAs in CRC and adjacent normal tissues