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Fig. 4 | Molecular Cancer

Fig. 4

From: CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA

Fig. 4

CircEZH2 promotes colorectal tumorigenesis, growth and metastasis in vivo. A Image of subcutaneous tumor xenografts in control and circEZH2 KD groups. B The tumor growth curves of xenografts were plotted in control and circEZH2 KD groups. C The tumor weights of xenografts were measured. D BALB/c nude mice injected with cells (control and circEZH2 KD; Five mice per group) via tail vein were imaged at 40 days by in vivo imaging system to evaluate the whole metastasis. E Representative images of H&E staining of lung metastasis loci. Scale bar = 200 μm. F The number of metastatic nodules was counted in the whole lung. G Scheme for the AOM/DSS-induced colon cancer model in ApcMin/+ mice. One week before AOM injection, AAV-control and AAV-circEZH2-OE were administered by enema. H Representative images of colon tissues in control and circEZH2-OE mice. Red arrows indicate visible tumors. I Hematoxylin and eosin (H&E) staining of colon tumors from control and circEZH2-OE mice. J-L The tumor number, average tumor size and length of colon in control and circEZH2-OE groups were analyzed. M The expression levels of EZH2 mRNA and circEZH2 in control and circEZH2-OE mice were detected by qRT-PCR assays. Data were showed as mean ± SD. # P > 0.05, *P < 0.05, **P < 0.01

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