Fig. 6From: CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNACircEZH2 promotes CRC progression by the sponge effect towards miR-133b. A The expression level of miR-133b in HCT116 and SW620 cells was verified by qRT-PCR. B-F CCK-8, plate colony-formation, EdU incorporation, wound-healing and transwell assays were performed to determine the proliferation and migration abilities of control and miR-133b-overexpressed HCT116 and SW620 cells. G The expression levels of EZH2 mRNA and circEZH2 in circEZH2-overexpressed HT-29 cells were verified by qRT-PCR. H The expression levels of circEZH2 and miR-133b in control, circEZH2-OE, miR-133b-OE and circEZH2-OE + miR-133b-OE-treated HT-29 cells were verified by qRT-PCR. I and J Colony-formation and transwell assays were performed to determine the proliferation and migration abilities of control, circEZH2-OE, miR-133b-OE and circEZH2-OE + miR-133b-OE-treated HT-29 cells. Data were showed as mean ± SD. # P > 0.05, **P < 0.01Back to article page