Fig. 2

circFBXO7 acts as a tumor suppressor and inhibits the proliferation, migration and invasion of ovarian cancer cells. A circFBXO7 expression in different ovarian cancer cell lines, assessed by qRT-PCR. B The expression of circFBXO7 and linear-FBXO7 in A2780 and MDAH2774 cells transfected with circFBXO7 or mock plasmids, as assessed by qRT-PCR. C Growth curve of A2780 and MDAH2774 cells transfected with circFBXO7 or mock plasmids as measured using CCK-8 assays. D Proliferation of A2780 and MDAH2774 cells transfected with circFBXO7 or mock plasmids as determined by colony formation assay. E Migration ability of A2780 and MDAH2774 cells transfected with circFBXO7 or mock plasmids. F Invasion ability of A2780 and MDAH2774 cells transfected with circFBXO7 or mock plasmids. G Western blot analysis of the expression of VIM and snail in A2780 and MDAH2774 cells transfected with circFBXO7 or mock plasmids. H Tumor volume and weight of nude mice injected with circFBXO7 and mock plasmids in right and left side, respectively. I Intraperitoneal injection of circFBXO7 overexpression cells into nude mice. *** P < 0.001, ** P < 0.01, * P < 0.05