Fig. 10
From: CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p
Splicing factor QKI accelerates the biogenesis of circBCAR3. A PCR analysis of circBCAR3 expression in EC109 cells after transfection with shRNAs against various splicing factors. B Multiple QKI binding sequences were found in the flanking of circBCAR3. C RIP assay using QKI antibody was conducted for assessing the binding of circBCAR3 and QKI. D PCR examined the expression of QKI in 45 paired esophageal cancer and adjacent nontumor tissues. E Effects of silenced QKI on expression of circBCAR3 and linear BCAR3 were revealed by PCR analysis. ** p < 0.01, *** p < 0.001