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Fig. 11 | Molecular Cancer

Fig. 11

From: CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p

Fig. 11

Hypoxia-induced E2F7 activated the transcription of QKI. A The heatmap and B volcano plot showing the dysregulated expression of genes in esophageal cancer cells under hypoxia treatment. C Metascape was used to perform the GO enrichment analysis. D The expression of E2F7 in 182 esophageal cancer tissues was obtained from the GEPIA database. E PCR analysis of E2F7 and QKI expression in EC109 cells under hypoxia. F The DNA motif of E2F7 and its potential binding site in the promotor of QKI were predicted from JASPAR website. G Luciferase assay was performed to detect whether E2F7 silencing can change the activity of the reporter vector carrying wild or mutant fragments of QKI promoter. H PCR analysis of QKI expression after E2F7 knockdown. I GEPIA database was used to evaluate the expression correlation between E2F7 and QKI, E2F7 and TNPO1, QKI and TNPO1 in 182 esophageal cancer tissues. *** p < 0.001

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